Research and Innovation

We are proud to offer your child with bronchopulmonary dysplasia (BPD) the very latest research-driven care. Our doctors are at the forefront of bronchopulmonary dysplasia and pulmonary hypertension (PH) research. We are a part of national organizations working to improve care for BPD and PH. These include the following:

• The BPD Collaborative, a national and international group of multidisciplinary teams dedicated to optimizing outcomes of infants and children with severe BPD. We are the only center in Northern California to participate. By participating in research, our team helps create future novel treatments, like stem cell therapies or identifying risk factors that answer why some premature babies have more severe BPD.
• Pediatric Pulmonary Hypertension Network (PPHNet), an association of medical professionals and centers focused on all aspects of pediatric pulmonary hypertension. Our doctors participate in formulating national recommendations for newborn pulmonary hypertension care.

Our CRIB Program is continuously seeking to discover new treatments and cures for BPD and PH. The team will likely approach you to ask if you are interested in participating in one of our clinical trials and studies. You also may be asked about enrolling your child in our voluntary data registries, which helps us improve our care.

Research studies

Our doctors were a part of the following recently published studies on BPD, PH, and prematurity:

• Respiratory Outcomes for Ventilator-Dependent Children With Bronchopulmonary Dysplasia. Pediatrics Manimtim, W. M., Agarwal, A., Alexiou, S., Levin, J. C., Aoyama, B., Austin, E. D., Bansal, M., Bauer, S. E., Cristea, A. I., Fierro, J. L., Garey, D. M., Hayden, L. P., Kaslow, J. A., Miller, A. N., Moore, P. E., Nelin, L. D., Popova, A. P., Rice, J. L., Tracy, M. C., Baker, C. D., Dawson, S. K., Eldredge, L. C., Lai, K., Rhein, L. M., Siddaiah, R., Villafranco, N., McGrath-Morrow, S. A., Collaco, J. M. 2023; 151 (5)  
• Role of Left Atrial Hypertension in Pulmonary Hypertension Associated With Bronchopulmonary Dysplasia. Frontiers in Pediatrics Sullivan, R. T., Tandel, M. D., Bhombal, S., Adamson, G. T., Boothroyd, D. B., Tracy, M., Moy, A., Hopper, R. K. 2022; 1012136
• Approaches to Interdisciplinary Care for Infants With Severe Bronchopulmonary Dysplasia: A Survey of the Bronchopulmonary Dysplasia Collaborative. American Journal of Perinatology Cristea, A. I., Tracy, M. C., Bauer, S. E., Guaman, M. C., Welty, S. E., Baker, C. D., Bhombal, S., Collaco, J. M., Courtney, S. E., DiGeronimo, R. J., Eldredge, L. C., Gibbs, K., Hayden, L. P., Keszler, M., Lai, K., McGrath-Morrow, S. A., Moore, P. E., Rose, R., Sindelar, R., Truog, W. E., Nelin, L. D., Abman, S. 2022
• Daycare Attendance is Linked to Increased Risk of Respiratory Morbidities in Children Born Preterm With Bronchopulmonary Dysplasia. The Journal of Pediatrics McGrath-Morrow, S. A., Agarwal, A., Alexiou, S., Austin, E. D., Fierro, J. L., Hayden, L. P., Lai, K., Levin, J. C., Manimtim, W. M., Moore, P. E., Rhein, L. M., Rice, J. L., Sheils, C. A., Tracy, M. C., Bansal, M., Baker, C. D., Cristea, A. I., Popova, A. P., Siddaiah, R., Villafranco, N., Nelin, L. D., Collaco, J. M. 2022
• Insurance Coverage and Respiratory Morbidities in Bronchopulmonary Dysplasia. Pediatric Pulmonology Collaco, J. M., Tracy, M. C., Sheils, C. A., Rice, J. L., Rhein, L. M., Nelin, L. D., Moore, P. E., Manimtim, W. M., Levin, J. C., Lai, K., Hayden, L. P., Fierro, J. L., Austin, E. D., Alexiou, S., Agarwal, A., Villafranco, N., Siddaiah, R., Popova, A. P., Cristea, I. A., Baker, C. D., Bansal, M., McGrath-Morrow, S. A. 2022
• Summary for Clinicians: Clinical Practice Guidelines for Outpatient Respiratory Management of Infants, Children, and Adolescents With Post-Prematurity Respiratory Disease. Annals of the American Thoracic Society Eldredge, L. C., Levin, J. C., Tracy, M. C., Cristea, A. I., Baker, C. D., Ruminjo, J. K., Thomson, C. C. 2022
• Ventilatory Strategies in Infants With Established Severe Bronchopulmonary Dysplasia: A Multicenter Point Prevalence Study. The Journal of Pediatrics McKinney, R. L., Napolitano, N., Levin, J. J., Kielt, M., Abman, S. H., Guaman, M. C., Rose, R. S., Courtney, S. E., Matlock, D., Agarwal, A., Leeman, K. T., Sanlorenzo, L. A., Sindelar, R., Collaco, J. M., Baker, C. D., Hannan, K. E., Douglass, M., Eldredge, L. C., Lai, K., McGrath-Morrow, S. A., Tracy, M. C., Truog, W., Lewis, T., Murillo, A. L., Keszler, M. 2021
• Progressive Metabolic Abnormalities Associated With the Development of Neonatal Bronchopulmonary Dysplasia. Nutrients Ye, C., Wu, J., Reiss, J. D., Sinclair, T. J., Stevenson, D. K., Shaw, G. M., Chace, D. H., Clark, R. H., Prince, L. S., Ling, X. B., Sylvester, K. G. 2022; 14 (17)
• Data-Driven Longitudinal Characterization of Neonatal Health and Morbidity. Science Translational Medicine De Francesco, D., Reiss, J. D., Roger, J., Tang, A. S., Chang, A. L., Becker, M., Phongpreecha, T., Espinosa, C., Morin, S., Berson, E., Thuraiappah, M., Le, B. L., Ravindra, N. G., Payrovnaziri, S. N., Mataraso, S., Kim, Y., Xue, L., Rosenstein, M. G., Oskotsky, T., Marić, I., Gaudilliere, B., Carvalho, B., Bateman, B. T., Angst, M. S., Prince, L. S., Blumenfeld, Y. J., Benitz, W. E., Fuerch, J. H., Shaw, G. M., Sylvester, K. G., Stevenson, D. K., Sirota, M., Aghaeepour, N. 2023; 15 (683): eadc9854

If you’re seeking an evaluation from our CRIB Program, please ask your child’s doctor for a referral.